法医学講座

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教室概要

初代土井十二教授、錫谷徹教授、永野耐造教授、若杉長英教授、辻力教授と続き平成15年4月に現在の六代目近藤稔和教授が金沢大学から赴任して現在に至っています。

近藤教授赴任以来、毎年100体以上の法医解剖を行っており、解剖体数は増加の一途をたどり平成19年は150体を越え、現在では毎年200体を優に超える解剖を行っています。法医実務に追われる日々であるが、和歌山県で唯一司法解剖を行う機関として、社会正義を支える重要な役割を担う法医学の重責を全うするため教室を挙げて頑張っています。勿論、実務のみに終わることなく教育、研究にも励んでいます。研究は「侵襲と生体反応」という一つの大きなテーマを掲げて、法医学から最先端の細胞生物学にまで及ぶ研究を展開しています。

具体的には、サイトカインやケモカインを指標とする皮膚損傷の受傷後経過時間判定の法医実務への応用。さらには、遺伝子改変動物を用いて、皮膚損傷治癒の分子メカニズム、外傷性ショックや薬物中毒の分子病態生理の解明を目指しています。それらの研究成果を法医学分野はもとより法医学以外の領域にも積極的に発表しており、それぞれの分野で高い評価を得ているものと自負しております。

また、教室には常にMD-PｈDコースの学生や法医学に興味はある学生が出入りし、研究や実務に参加して研究と法医実務を体験しながら勉強する環境を提供することで、法医学の将来を担う人材の育成にも努めています。

教育概要

集団の中で発生した異状死亡の原因を解析理解することができるようになるために、社会における医と法の多数の接点を理解し、すべての医行為の責務を充分果たし得る態度を習得することを目標としています。

また、教育内容としては、死と死後経過時間、損傷と死因、窒息、中毒、交通事故損傷、嬰児の異状死、異常環境による死、内因性急死、性に関する異常、集団の中における個人識別などを講義し、血液型判定等のdemonstrationを取り入れ、スライド示説ならびに可能な限り、多くの司法解剖を見学させることにより、総合的把握理解に努めています。

スタッフ紹介

教授 近藤　稔和 kondot@wakayama-med.ac.jp
准教授 石田　裕子 iyuko@wakayama-med.ac.jp
講師 野坂　みずほ menosaka@wakayama-med.ac.jp
講師 石上　安希子 a-ishi@wakayama-med.ac.jp
助教 山本　寛記 h-ymmt@wakayama-med.ac.jp

研究概要

当教室では、様々な外的刺激に対する生体反応におけるサイトカインやケモカインなどの生理活性物質の役割解析をするために、 法医学的に重要と考えられる障害または病態モデルを確立し、遺伝子改変マウスを用いた研究を行っています。

  1. 皮膚損傷治癒モデル
  2. 急性または慢性肺障害モデル
  3. 急性肝障害モデル
  4. 急性腎障害モデル
  5. 急性膵障害モデル

研究業績

  1. Ishigami A, Hata S, Ishida Y, Nosaka M, Kuninaka Y, Yamamoto H, Shimada E, Hashizume Y, Takayasu T, Kimura A, Furukawa F, Kondo T. Complete decapitation by a self-constructed guillotine in a burned body – complex suicide or postmortem burning? Int J Legal Med. 135(1):301-305. 2021 doi: 10.1007/s00414-020-02323-y. PMID: 32474665
  2. Nosaka M, Ishida Y, Kuninaka Y, Ishigami A, Taruya A, Shimada E, Hashizume Y, Yamamoto H, Kimura A, Furukawa F, Kondo T. Intrathrombotic appearances of AQP-1 and AQP-3 in relation to thrombus age in murine deep vein thrombosis model. Int J Legal Med. 135(2):547-553. 2021 doi: 10.1007/s00414-020-02482-y. PMID: 33410924
  3. shigami A, Kashiwagi M, Ishida Y, Hara K, Nosaka M, Matsusue A, Yamamoto H, Waters B, Kondo T, Kubo SI. A comparative study of pleural effusion in water area, water temperature and postmortem interval in forensic autopsy cases of drowning. Sci Rep. 11(1):21528. 2021. doi: 10.1038/s41598-021-01047-2. PMID: 34728742.
  4. Kuninaka Y, Ishida Y, Nosaka M, Ishigami A, Taruya A, Shimada E, Kimura A, Yamamoto H, Ozaki M, Furukawa F, Kondo T. Forensic significance of intracardiac heme oxygenase-1 expression in acute myocardial ischemia. Sci Rep. 11(1):21828. 2021. doi: 10.1038/s41598-021-01102-y. PMID: 34750390.
  5. Ishigami A, Iwahashi Y, Ishida Y, Nosaka M, Kuninaka Y, Yamamoto H, Hashizume Y, Kondo T. Fatal injury by high-pressure water jet unit – A case report. J Forensic Leg Med. 2021 84:102270. doi: 10.1016/j.jflm.2021.102270. PMID: 34742124. Online ahead of print
  1. Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Taruya A, Furuta M, Mukaida N, Kondo T. Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3–CCR5 axis. Nat Commun. 11(1):5994. 2020. doi: 10.1038/s41467-020-19763-0. PMID: 33239616
  2. Ishida Y, Kuninaka Y, Yamamoto Y, Nosaka M, Kimura A, Furukawa F, Mukaida N, Kondo T. Pivotal involvement of the CX3CL1-CX3CR1 axis for the recruitment of M2 tumor-associated macrophages in skin carcinogenesis. J Invest Dermatol. 140(10):1951-1961. e6. 2020 doi: 10.1016/j.jid.2020.02.023. PMID: 32179066
  3. Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Taruya A, Ozaki M, Tanaka A, Mukaida N, Kondo T. Crucial Involvement of IL-6 in Thrombus Resolution in Mice via Macrophage Recruitment and the Induction of Proteolytic Enzymes. Front Immunol. 10:3150. 2020 doi: 10.3389/fimmu.2019.03150. PMID: 32117207
  4. Nosaka M, Ishida Y, Kuninaka Y, Taruya A, Kimura A, Shimada E, Yamamoto H, Michiue T, Furukawa F, Kondo T. The application of autophagy to thrombus age estimation in murine deep vein thrombosis model. Int J Legal Med. 134(3):1061-1066. 2020 doi: 10.1007/s00414-019-02168-0. PMID: 31713680.
  5. Kuninaka Y, Ishida Y, Nosaka M, Shimada E, Kimura A, Ozaki M, Hata S, Michiue T, Yamamoto H, Furukawa F, Eisenmenger W, Kondo T. Forensic pathological study on temporal appearance of dendritic cells in skin wounds. Int J Legal Med. 134(2):597-601. 2020 doi: 10.1007/s00414-019-02185-z. PMID: 31792610.
  6. Yamamoto H, Takayasu T, Ishida Y, Nosaka M, Hata S, Kuninaka Y, Shimada E, Hashizume Y, Ishigami A, Ozaki M, Kawaguchi M, Kimura A, Furukawa F, Kondo T. A case of complex suicide due to acute nicotine intoxication caused by cigarette ingestion. Int J Legal Med. 134(3):997-1002. 2020 doi: 10.1007/s00414-019-02228-5. PMID: 31836934.
  7. Katayama Y, Tanaka A, Taruya A, Kashiwagi M, Nishiguchi T, Ozaki Y, Matsuo Y, Kitabata H, Kubo T, Shimada E, Kondo T, Akasaka T. Feasibility and Clinical Significance of In Vivo Cholesterol Crystal Detection Using Optical Coherence Tomography. Arterioscler Thromb Vasc Biol. 40(1):220-229. 2020 doi: 10.1161/ATVBAHA.119.312934. PMID: 31619064
  8. Katayama Y, Tanaka A, Taruya A, Kashiwagi M, Nishiguchi T, Ozaki Y, Shiono Y, Shimamura K, Kitabata H, Kubo T, Hozumi T, Ishida Y, Kondo T, Akasaka T. Increased plaque rupture forms peak incidence of acute myocardial infarction in winter. Int J Cardiol. 320:18-22. 2020 doi: 10.1016/j.ijcard.2020.07.011. PMID: 32679138
  9. Yokoyama M, Chihara N, Tanaka A, Katayama Y, Taruya A, Ishida Y, Yuzaki M, Honda K, Nishimura Y, Kondo T, Akasaka T, Kato N. A biodegradable microneedle sheet for intracorporeal topical hemostasis. Sci Rep. 10(1):18831. 2020 doi:10.1038/s41598-020-75894-w. PMID: 33139831 PMCID: PMC7608660
  10. Zhao J, Nakahira K, Kimura A, Kyotani Y and Yoshizumi M. Upregulation of iNOS Protects Cyclic Mechanical Stretch-Induced Cell Death in Rat Aorta Smooth Muscle Cells. Int J Mol Sci. 21(22):E8660. 2020 doi: 10.3390/ijms21228660. PMID: 33212839
  1. Murakami K, Kawaguchi T, Hashizume Y, Kitamura K, Okada M, Okumoto K, Sakamoto S, Ishida Y, Nosaka M, Kimura A, Takatsu A, Kondo T. Suicide by plastic bag suffocation combined with the mixture of citric acid and baking soda in an adolescent. Int J Legal Med. 133(1):177-180. 2019
  2. Yahata T, Mizoguchi M, Kimura A, Orimo T, Toujima S, Kuninaka Y, Nosaka M, Ishida Y, Sasaki I, Fukuda-Ohta Y, Hemmi H, Iwahashi N, Noguchi T, Kaisho T, Kondo T, Ino K. Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9-genome editing promotes antitumor immunity and suppresses ovarian cancer progression. Cancer Sci. 110(4):1279-1292. 2019
  3. Takayasu T, Yamamoto H, Ishida Y, Nosaka M, Kuninaka Y, Shimada E, Kawaguchi M, Kimura A, Kondo T. Postmortem distribution of acephate and its metabolite methamidophos in body fluids and organ tissues of an intoxication case. Forensic Sci Int. 300:e38-e43. 2019
  4. Ishida Y, Kuninaka Y, Nosaka M, Furuta M, Kimura A, Taruya A, Yamamoto H, Shimada E, Akiyama M, Mukaida N, Kondo T. CCL2-mediated reversal of impaired skin wound healing in diabetic mice by normalization of neovascularization and collagen accumulation. J Invest Dermatol. pii: S0022-202X(19)31786-5. 2019
  1. Ishida Y, Kuninaka Y, Furukawa F, Kimura A, Nosaka M, Fukami M, Yamamoto H, Kato T, Shimada E, Hata S, Takayasu T, Eisenmenger W, Kondo T. Immunohistochemical analysis on aquaporin-1 and aquaporin-3 in skin wounds from the aspects of wound age determination. Int J Legal Med 132(1):237-242. 2018
  2. Ishida Y, Kuninaka Y, Nosaka M, Shimada E, Hata S, Yamamoto H, Hashizume Y, Kimura A, Furukawa F, Kondo T. Forensic application of epidermal AQP3 expression to determination of wound vitality in human compressed neck skin. Int J Legal Med. 132(5):1375-1380. 2018
  3. Kimura A, Ishida Y, Furuta M, Nosaka M, Kuninaka Y, Taruya A, Mukaida N and Kondo T. Protective Roles of Interferon-? in Cardiac Hypertrophy Induced by Sustained Pressure Overload. J Am Heart Assoc. 7(6): pii: e008145. 2018
  4. Inaba Y, Kanazawa N, Yoshimasu T, Shimokawa T, Nosaka M, Kondo T, Furukawa F. Severer lupus erythematosus-like skin lesions in MRL/lpr mice with homozygous Kit(wsh/wsh) mutation. Mod Rheumatol. 28(2):319-326. 2018
  5. Shima T, Yamamoto Y, Kanazawa N, Murata KY, Ito H, Kondo T, Yuan J, Hashiguchi A, Takashima H, Furukawa F. Repeated hyperhidrosis and chilblain-like swelling with ulceration of the fingers and toes in hereditary sensory and autonomic neuropathy type II. J Dermatol. 45(11):e308-e309. 2018
  6. Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Taruya A, Furuta M, Mukaida N, Kondo T. Contribution of the TNF-α (Tumor Necrosis Factor-α)-TNF-Rp55 (Tumor Necrosis Factor Receptor p55) Axis in the Resolution of Venous Thrombus. Arterioscler Thromb Vasc Biol. 38(11):2638-2650. 2018
  7. Mizoguchi M, Ishida Y, Nosaka M, Kimura A, Kuninaka Y, Yahata T, Nanjo S, Toujima S, Minami S, Ino K, Mukaida N, Kondo T. Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice. PLoS One. 13(11):e0207085. 2018
  1. Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Hemmi H, Sasaki I, Kaisho T, Mukaida N, Kondo T. Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration. Sci Rep. 7(1):16833. 2017??
  2. Nosaka M, Ishida Y, Kimura A, Yamamoto H, Kato T, Kuninaka Y, Shimada E, Kondo T. Detection of intrathrombotic endothelial progenitor cells and its application to thrombus age estimation in a murine deep vein thrombosis model. Int J Legal Med. 131(6):1633-1638. 2017
  3. Yamamoto H, Takayasu T, Nosaka M, Kimura A, Ishida Y, Kawaguchi T, Fukami M, Okada M, Kondo T. Fatal acute intoxication of accidentally ingested nifedipine in an infant –A case report. Legal Medicine, 24:12–18. 2017
  4. Cecchi R, Muciaccia B, Ciallella C, Di Luca NM, Kimura A, Sestili C, Nosaka M, Kondo T. Ventricular androgenic-anabolic steroid-related remodeling: an immunohistochemical study. Int J Legal Med. 131(6):1589-1595. 2017
  5. Cecchetto G, Bajanowski T, Cecchi R, Favretto D, Grabherr S, Ishikawa T, Kondo T, Montisci M, Pfeiffer H, Bonati MR, Shokry D, Vennemann M, Ferrara SD. Back to the Future - Part 1. The medico-legal autopsy from ancient civilization to the post-genomic era. Int J Legal Med. 131(4):1069-1083. 2017
  6. Ferrara SD, Cecchetto G, Cecchi R, Favretto D, Grabherr S, Ishikawa T, Kondo T, Montisci M, Pfeiffer H, Bonati MR, Shokry D, Vennemann M, Bajanowski T. Back to the Future - Part 2. Post-mortem assessment and evolutionary role of the bio-medicolegal sciences. Int J Legal Med. 131(4):1085-1101. 2017
  7. Kondo T. Immune systems in skin wound healing. Trends in Immunotherapy. 1(2):57. 2017
  8. Nosaka M, Ishida Y, Kimura A, Yamamoto H, Kuninaka Y, Shimada E, Okumoto K, Okada M, Hata S, and Kondo T. Influence of circadian rhythm on thrombus formation of murine deep vein thrombosis model. Ann Hematol Oncol. 4(9): id1171 2017
  9. Zhao J, Nishimura Y, Kimura A, Ozawa K, Kondo T, Tanaka T, Yoshizumi M. Chemokines protect vascular smooth muscle cells from cell death induced by cyclic mechanical stretch. Sci Rep. 7(1):16128. 2017
  10. Takayasu T, Yamamoto H, Ishida Y, Nosaka M, Kawaguchi M, Kuninaka Y, Kimura A, Kondo T. Postmortem distribution of chlorpyrifos-methyl, fenitrothion, and their metabolites in body fluids and organ tissues of an intoxication case. Leg Med (Tokyo). 29:44-50. 2017
  11. Ozaki M, Nishioka K, Kimura A, Kondo T, Nakao N. Activation of the arachidonic acid metabolic pathway and induction of sleep disturbance by sacral osteoblastoma: A case report. Mol Clin Oncol, 7(2):237-240. 2017?
  12. Doi N, Nakatani Y, Inaba Y, Kondo T, Furukawa T, Kanazawa N. Acute-phase effects of single-time topical or systemic corticosteroid application immediately after hot water-induced burn injury of various grades. Trends in Immunotherapy, 1(1):19-27. 2017
  13. Inaba Y, Kanazawa N, Yoshimasu T, Shimokawa T, Nosaka M, Kondo T, Furukawa F. Severer lupus erythematosus-like skin lesions in MRL/lpr mice with homozygous Kit(wsh/wsh) mutation. Mod Rheumatol. 11:1-8. 2017.
  1. Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Hama M, Kawaguchi T, Sakamoto S, Shinozaki K, Iwahashi Y, Takayasu T, Kondo T. Exaggerated arsenic nephrotoxicity in female mice through estrogen-dependent impairments in the autophagic flux. Toxicology, 339:9-18. 2016
  2. Nosaka M, Ishida Y, Kimura A, Kawaguchi T, Yamamoto H, Kuninaka Y, Kondo T. Immunohistochemical detection of intrathrombotic fibrocytes and its application to thrombus age estimation in murine deep vein thrombosis model. Int J Legal Med, 131:179-183. 2016
  3. Shimomatsu T, Kanazawa N, Mikita N, Nakatani Y, Li HJ, Inaba Y, Ikeda T, Kondo T, Furukawa F. The effect of hydroxychloroquine on lupus erythematosus-like skin lesions in MRL/lpr mice. Mod Rheumatol, 26:744-748. 2016
  4. 吉良英知，尾藤吉将，川口敬士，近藤稔和．法医実務における生化学検査の応用－死体血サイログロブリン濃度の意義－．法医病理，22(2):87-89. 2016
  1. Kimura A, Ishida Y, Nosaka M, Shiraki M, Hama M, Kawaguchi T, Kuninaka Y, Shimada E, Yamamoto H, Takayasu T, Kondo T. Autophagy in skin wounds: a novel marker for vital reactions. Int J Legal Med, 129:537-541. 2015
  2. Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Kawaguchi T, Hama M, Sakamoto S, Shinozaki K, Eisenmenger W, Kondo T. Immunohistochemical analysis on MMP-2 and MMP-9 for wound age determination. Int J Legal Med, 129:1043-1048. 2015
  3. Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Shimada E, Yamamoto H, Nishiyama K, Inaka S, Takayasu T, Eisenmenger W, Kondo T. Detection of endothelial progenitor cells in human skin wounds and its application for wound age determination. Int J Legal Med, 129:1049-1054. 2015
  4. Nosaka M, Ishida Y, Kimura A, Hama M, Kawaguchi T, Yamamoto H, Kuninaka Y, Shimada E, Kondo T. Immunohistochemical detection of intrathrombotic IL-6 and its application to thrombus age estimation. Int J Legal Med, 129:1021-1025. 2015 ???
  5. Kobayashi A, Tanizaki Y, Kimura A, Ishida Y, Nosaka M, Toujima S, Kuninaka Y, Minami S, Ino K, Kondo T. AG490, a Jak2 inhibitor, suppressed the progression of murine ovarian Cancer. Eur J Pharmacol, 766:63-75. 2015
  6. Wang Y, Yamamoto Y, Kuninaka Y, Kondo T, Furukawa F. Forensic Potential of MMPs and CC Chemokines for Wound Age Determination. J Forensic Sci, 60:1511-1515. 2015
  1. Nosaka M, Ishida Y, Kimura A, Kondo T. Immunohistochemical detection of intrathrombotic macrophage-derived cytokines and its application to thrombus age estimation in murine deep vein thrombosis model. Int J Legal Med, 127:937-942. 2013
  2. Kawaguchi T, Hama M, Abe M, Suenaga T, Ishida Y, Nosaka M, Kuninaka Y, Kawaguchi M, Yoshikawa N, Kimura A, Kondo T. Sudden unexpected neonatal death due to late onset group B streptococcal sepsis-A case report. Leg Med (Tokyo), 15:260-263. 2013
  1. Ishida Y, Kimura A, Kuninaka Y, Inui M, Matsushima K, Mukaida N, Kondo T. Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing. J Clin Invest, 122:711-721. 2012
  2. Kimura A, Ishida Y, Inagaki M, Nakamura Y, Sanke T, Mukaida N, Kondo T. Interferon-g is protective in cisplatin-induced renal injury by enhancing autophagic flux. Kidney Int, 82 : 1093-1104. 2012
  3. Hama M, Abe M, Kawaguchi T, Ishida Y, Nosaka M, Kuninaka Y, Kimura A, Kondo T.? A case of myocardial infarction in a young female with subclinical hyperthyroidism. Int J Cardiol, 158:e23-25. 2012
  4. Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Takayasu T, Eisenmenger W, Kondo T. Immunohistochemical analysis on cyclooxygenase-2 for wound age determination. Int J Legal Med， 126: 435-440. 2012
  5. Nosaka M, Ishida Y, Kuninaka Y, Kimura A, Kondo T. Immunohistochemical detection of uPA, tPA, and PAI-1 in a stasis-induced deep vein thrombosis model and its application to thrombus age estimation. Int J Legal Med, 126: 421-425. 2012
  6. Takayasu T, Ishida Y, Nosaka M, Kawaguchi M, Kuninaka Y, Kimura A, Kondo T.? High concentration of methidathion detected in a fatal case of organophosphate-poisoning. Leg Med (Tokyo) 14:263-266. 2012
  7. Lu P, Li L, Liu G, Baba T, Ishida Y, Nosaka M, Kondo T, Zhang X, Mukaida N. Critical role of TNF-α-induced macrophage VEGF and iNOS production in the experimental corneal neovascularization. Invest Ophthalmol Vis Sci, 53:3516-3526. 2012
  8. Hama-Tomioka K, Kinoshita H, Nakahata K, Kondo T, Azma T, Kawahito S, Hatakeyama N, Matsuda N. Roles of neuronal nitric oxide synthase, oxidative stress, and propofol in N-methyl-D-aspartate-induced dilatation of cerebral arterioles. Br J Anaesth, 108:21-29. 2012
  9. Hirai Y, Muragaki Y, Itoh S, Oikawa K, Juri M, Kondo T, Okamura Y. Fibulin-5 protein is reduced in the lung of patients with spontaneous pneumothorax who are under 25 years old. Ann Thorac Cardiovasc Surg, 18: 200-205. 2012
  1. Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Inui M, Mukaida N, Kondo T. Absence of IFN-g accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice. J Clin Invest, 121:2911-2920. 2011
  2. Inui M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T. Protective roles of CX3CR1-mediated signals in toxin A-induced enteritis through the induction of heme oxygenase-1 expression. J Immunol, 186:423-431. 2011
  3. Kimura A, Ishida Y, Hayashi T, Nosaka M, Kondo T. Estimating time of death based on the biological clock. Int J Legal Med, 125:385-391. 2011
  4. An JL, Ishida Y, Kimura A, Kondo T. Immunohistochemical examination of intracerebral aquaporin-4 expression and its application for differential diagnosis between freshwater and saltwater drowning. Int J Legal Med, 125:59-65. 2011
  5. Fujii H, Baba T, Ishida Y, Kondo T, Yamagishi M, Kawano M, Mukaida N. Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice. Arthritis Rheum, 63:96-106. 2011
  6. Morita S, Sakagashira S, Shimajiri Y, Eberhardt NL, Kondo T, Sanke T. Autophagy protects against human islet amyloid polypeptide-associated apoptosis. J Diabetes Invest, 2:48-55. 2011
  7. 近藤稔和，石田裕子.　皮膚損傷の受傷後経過時間判定の研究と実際．法医病理，17:43-50. 2011
  1. Kimura A, Ishida Y, Wada T, Hisaoka T, Morikawa Y, Sugaya T, Mukaida N, Kondo T. The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation. Am J Pathol, 176:40-50. 2010
  2. Kostadinova FI, Baba T, Ishida Y, Kondo T, Popivanova BK, Mukaida N. Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice. J Leukoc Biol, 88:133-143. 2010
  3. Nosaka M, Ishida Y, Kimura A, Kondo T. Immunohistochemical detection of MMP-2 and MMP-9 in a stasis-induced deep vein thrombosis model and its application to thrombus age estimation. Int J Legal Med, 124:439-444. 2010
  4. An JL, Ishida Y, Kimura A, Kondo T. Forensic application of intrarenal aquaporin-2 expression for differential diagnosis between freshwater and saltwater drowning. Int J Legal Med, 124:99-104. 2010
  5. Kondo T, Ishida Y. Molecular pathology of wound healing. Forensic Sci Int, 203:93-98. 2010
  6. Nosaka M, Ishida Y, Kimura A, Kondo T. Time-dependent organic changes of intravenous thrombi in stasis-induced deep vein thrombosis model and its application to thrombus age determination. Forensic Sci Int, 195:143-147. 2010
  7. Takayasu T, Ishida Y, Kimura A, Nosaka M, Kawaguchi M, Kondo T. Postmortem distribution of ametryn in the blood and organ tissues in a herbicide-poisoning case. J Anal Toxicol, 34:287-291. 2010
  8. Takayasu T, Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Kawaguchi M, Kondo T. Distribution of carbamazepine and its metabolites carbamazepine-10,11-epoxide and iminostilbene in body fluids and organ tissues in five autopsy cases. Forensic Toxicol, 28:124–128. 2010
  9. Toyozawa S, Yamamoto Y, Ishida Y, Kondo T, Nakamura Y, Furukawa F. Immunohistochemical analysis of CXCR4 expression in fibrohistiocytic tumors. Acta Histochem Cytochem, 43:45-50. 2010
  1. Ishibe T, Kimura A, Ishida Y, Takayasu T, Hayashi T, Tsuneyama K, Matsushima K, Sakata I, Mukaida N, Kondo T. Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist. Lab Invest, 89:68-79. 2009
  2. Popivanova BK, Kostadinova FI, Furuichi K, Shamekh MM, Kondo T, Wada T, Egashira K, Mukaida N. Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice. Cancer Res, 69:7884-7892. 2009
  3. Hayashi T, Ishida Y, Mizunuma S, Kimura A, Kondo T. Differential diagnosis between freshwater drowning and saltwater drowning based on intrapulmonary aquaporin-5 expression. Int J Legal Med, 123:7-13. 2009
  4. Ishida Y, Kimura A, Takayasu T, Eisenmenger W, Kondo T. Detection of fibrocytes in human skin wounds and its application for wound age determination. Int J Legal Med, 123:299-304. 2009
  5. Nosaka M, Ishida Y, Kimura A, Kondo T. Time-dependent appearance of intrathrombus neutrophils and macrophages in a stasis-induced deep vein thrombosis model and its application to thrombus age determination. Int J Legal Med, 123:235-240. 2009
  6. An JL, Ishida Y, Kimura A, Tsokos M, Kondo T. Immunohistochemical detection of CCR2 and CX3CR1 in sepsis-induced lung injury. Forensic Sci Int, 192:e21-25. 2009
  7. Kaminaka C, Yamamoto Y, Yonei N, Kishioka A, Kondo T, Furukawa F. Phenol peels as a novel therapeutic approach for actinic keratosis and Bowen disease: prospective pilot trial with assessment of clinical, histologic, and immunohistochemical correlations. J Am Acad Dermatol, 60:615-625. 2009
  1. Ishida Y, Gao JL, Murphy PM. Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function. J Immunol, 180:569-579. 2008
  2. Ishida Y, Hayashi T, Goto T, Kimura A, Akimoto S, Mukaida N, Kondo T. Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis. J Immunol, 181:4208-4218. 2008
  3. Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, Oshima M, Fujii C, Mukaida N. Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest, 118:560-570. 2008
  4. Nosaka M, Ishida Y, Tanaka A, Hayashi T, Miyashita T, Kaminaka C, Eisenmenger W, Furukawa F, Kimura A. Aberrant expression of histo-blood group A type 3 antigens in vascular endothelial cells in inflammatory sites. J Histochem Cytochem, 56:223-231. 2008
  5. Ishida Y, Kimura A, Takayasu T, Eisenmenger W, Kondo T. Expression of oxygen-regulated protein 150 (ORP150) in skin wound healing and its application for wound age determination. Int J Legal Med, 122:409-414. 2008
  6. Fukube S, Hayashi T, Ishida Y, Kamon H, Kawaguchi M, Kimura A, Kondo T. Retrospective study on suicidal cases by sharp force injuries. J Forensic Leg Med, 15:163-167. 2008
  7. Ikematsu K, Takahashi H, Kondo T, Tsuda R, Nakasono I. Temporal expression of immediate early gene mRNA during the supravital reaction in mouse brain and lung after mechanical asphyxiation. Forensic Sci Int, 179:152-156. 2008
  8. Takayasu T, Ishida Y, Kimura A, Kawaguchi M, Kondo T. Distribution of zolpidem in body fluids and organ tissues in five autopsy cases. Forensic Toxicol, 26:80-84. 2008
  9. Takayasu T, Hayashi T, Ishida Y, Nosaka M, Mizunuma S, Miyashita T, Kawaguchi M, Kimura A, Kondo T. A fatal intoxication from ingestion of 2-methyl-4-chlorophenoxyacetic acid (MCPA). J Anal Toxicol, 32:187-191. 2008
  10. Nakahata K, Kinoshita H, Hama-Tomioka K, Ishida Y, Matsuda N, Hatakeyama N, Haba M, Kondo T, Hatano Y. Cholinesterase inhibitor donepezil dilates cerebral parenchymal arterioles via the activation of neuronal nitric oxide synthase. Anesthesiology, 109:124-129. 2008
  11. Kiguchi N, Maeda T, Kobayashi Y, Kondo T, Ozaki M, Kishioka S. The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice. Eur J Pharmacol, 592:87-92. 2008
  12. Zhu BM, Ishida Y, Robinson GW, Pacher-Zavisin M, Yoshimura A, Murphy PM, Hennighausen L. SOCS3 Negatively Regulates the gp130-STAT3 Pathway in Mouse Skin Wound Healing. J Invest Dermatol, 128:1821-1829. 2008
  1. Hayashi T, Ishida Y, Kimura A, Iwakura Y, Mukaida N, Kondo T. IFN-g protects cerulein-induced acute pancreatitis by repressing NF-kB activation. J Immunol, 178:7385-7394. 2007
  2. Ishida Y, Kimura A, Kondo T, Hayashi T, Ueno M, Takakura N, Matsushima K, Mukaida N. Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration. Am J Pathol, 170:843-854. 2007
  3. Ishida Y, Kimura A, Kondo T, Hayashi T, Ueno M, Takakura N, Matsushima K, Mukaida N. Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration. Am J Pathol, 170:843-854. 2007
  4. Hayashi T, Ishida Y, Kimura A, Iwakura Y, Mukaida N, Kondo T. IFN-g protects cerulein-induced acute pancreatitis by repressing NF-κB activation. J Immunol, 178:7385-7394. 2007
  5. Hayashi T, Hirayama N, Ro A, Kageyama N, Ishida Y, Tsuneyama K, Kimura A, Fukunaga T, Kondo T. Severe brainstem compression by an unruptured giant vertebral aneurysm--an autopsy case. Leg Med, 9:322-325. 2007
  6. Miyashita T, Hayashi T, Ishida Y, Tsuneyama K, Kimura A, Kondo T. A fatal case of pontine hemorrhage related to methamphetamine abuse. J Forensic Leg Med, 14:444-447. 2007 Former title: Formerly known as the Journal of Clinical Forensic Medicine.
  7. Nakaya I, Wada T, Furuichi K, Sakai N, Kitagawa K, Yokoyama H, Ishida Y, Kondo T, Sugaya T, Kawachi H, Shimizu F, Narumi S, Haino M, Gerard C, Matsushima K, Kaneko S. Blockade of IP-10/CXCR3 promotes progressive renal fibrosis. Nephron Exp Nephrol, 107:e12-21. 2007
  8. Ogata M, Ago K, Ago M, Kondo T, Kasai K, Ishikawa T, Mizukami H. A Fatal Case of Hypothermia Associated With Hemorrhages of the Pectoralis Minor, Intercostal, and Iliopsoas Muscles. Am J Forensic Med Pathol, 28:348-352. 2007
  9. 小片　守，吾郷一利，吾郷美保子，中島弘志，池松和哉，近藤稔和，北　敏郎，田中宣幸．高齢者虐待―身体的?経済的虐待が原因で自殺したと判断された一剖検例―．犯罪学雑誌，73:208-213. 2007
  10. 石田裕子，向田直史，近藤稔和．皮膚損傷治癒とIL-1 receptor antagonist(IL-1ra)．臨床免疫?アレルギー科．47:245-251. 2007 （解説）
  1. Ishida Y, Kondo T, Kimura A, Matsushima K, Mukaida N. Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-?B activation and a reciprocal suppression of TGF-? signal pathway. J Immunol, 176:5598-5606. 2006
  2. Kimura A, Ishida Y, Hayashi T, Wada T, Yokoyama H, Sugaya T, Mukaida N, Kondo T. Interferon-? plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression. Am J Pathol, 169:1118-1128. 2006
  3. Ishida Y, Kondo T, Kimura A, Tsuneyama K, Takayasu T, Mukaida N. Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury. Eur J Immunol, 36:1028-1038. 2006
  4. Yang X, Lu P, Ishida Y, Kuziel WA, Fujii C, Mukaida N. Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization. Int J Cancer, 118:335-345. 2006
  5. Ishida Y, Takayasu T, Kimura A, Hayashi T, Kakimoto N, Miyashita T, Kondo T. Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice. Leg Med (Tokyo), 8:102-109. 2006
  6. Kimura A, Ishida Y, Hayashi T, Wada T, Yokoyama H, Sugaya T, Mukaida N, Kondo T. Interferon-g plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression. Am J Pathol, 169:1118-1128. 2006
  7. Ishida Y, Kondo T, Kimura A, Matsushima K, Mukaida N. Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kB activation and a reciprocal suppression of TGF-b signal pathway. J Immunol, 176:5598-5606. 2006
  8. Ishida Y, Takayasu T, Kimura A, Hayashi T, Kakimoto N, Miyashita T, Kondo T. Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice. Leg Med(Tokyo), 8:102-109. 2006
  9. Ishida Y, Kondo T, Kimura A, Tsuneyama K, Takayasu T, Mukaida N. Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury. Eur J Immunol, 36:1028-1038. 2006
  10. Yang X, Lu P, Ishida Y, Kuziel WA, Fujii C, Mukaida N. Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization. Int J Cancer, 118:335-345. 2006
  11. Takahara A, Sugiyama A, Ishida Y, Satoh Y, Wang K, Nakamura Y, Hashimoto K. Long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H1 blocker terfenadine-induced torsades de pointes arrhythmias. Br J Pharmacol, 147:634-641. 2006
  12. Miyashita T, Kakimoto N, Ishida Y, Hayashi T, Kimura A, Tsokos M, Kondo T. Immunohistochemical expression of tumor necrosis factor-a in sepsis-induced lung injury. Forensic Sci Med Pathol, 2:103-108. 2006
  13. Nakahata K, Kinoshita H, Tokinaga Y, Ishida Y, Kimoto Y, Dojo M, Mizumoto K, Ogawa K, Hatano Y. Vasodilation mediated by inward rectifier K+ channels in cerebral microvessels of hypertensive and normotensive rats. Anesth Analg, 102:571-576. 2006
  14. Rieg S, Seeber S, Steffen H, Humeny A, Kalbacher H, Stevanovic S, Kimura A, Garbe C, Schittek B. Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites. J Invest Dermatol, 126:354-365. 2006
  1. Kimura A, Kanekura T, Saito Y, Sagawa K, Nosaka M, Kanzaki T, Tsuji T. Blood group A glycosphingolipid accumulation in the hair of patients with α-N-acetylgalactosaminidase deficiency. Life Sci 76:1817-1824. 2005
  2. Hayashi T, Ishida Y, Miyashita T, Kiyokawa H, Kimura A, Kondo T. Fatal water intoxication in a schizophrenic patient--an autopsy case. J Clin Forensic Med, 12:157-159. 2005
  3. Kimura A, Ishida Y, Wada T, Yokoyama H, Mukaida N, Kondo T. MRP-1 expression levels determine strain-specific susceptibility to sodium arsenic-induced renal injury between C57BL/6 and BALB/c mice. Toxicol Appl Pharmacol, 203:53-61. 2005
  4. Takayasu T, Kondo T. Assessment of drug screening kit instacheck for human samples. Jpn J Fornsic Toxicol, 23:209-213. 2005
  5. Yukawa K, Kishino M, Hoshino K, Shirasawa K, Kimura A, Tsubota Y, Owada-Makabe K, Bai T, Tanaka T, Ueyama T, Ichinose M, Takeda K, Akira S, Maeda M. The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy. Int J Mol Med, 15:73-78. 2005
  6. Yukawa K, Kishino M, Goda M, Liang XM, Kimura A, Tanaka T, Bai T, Owada-Makabe K, Tsubota Y, Ueyama T, Ichinose M, Maeda M, Takeda K, Akira S. STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy. Int J Mol Med, 15:225-230. 2005
  7. 石田裕子，近藤稔和，向田直史．Clostridium difficile toxin A 誘発腸炎におけるサイトカインの役割－IFN-gの生物学的役割－．炎症?再生, 25:507-511. 2005
  1. Ishida Y, Maegawa T, Kondo T, Kimura A, Iwakura Y, Nakamura S, Mukaida N. Essential Involvement of IFN-γ in Clostridium difficile Toxin A-Induced Enteritis. J Immunol. 172:3018-3025. 2004
  2. Ishida Y, Kondo T, Takayasu T, Iwakura Y, Mukaida N. The Essential Involvement of Cross-Talk between IFN-γ and TGF-β in the Skin. Wound-Healing Process. J Immunol, 172:1848-1855. 2004
  3. Ishida Y, Kondo T, Tsuneyama K, Lu P, Takayasu T, Mukaida N. The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced liver injury in mice. J Leukoc Biol, 75:59-67. 2004
  4. Hayashi T, Ishida Y, Kimura A, Takayasu T, Eisenmenger W, Kondo T. Forensic application of VEGF expression to skin wound age determination. Int J Legal Med, 118:320-325. 2004
  5. Ikematsu K, Tsuda R, Kondo T, Kondo H, Ozawa K, Ogawa S, Nakasono I. The expression of '150-kDa oxygen regulated protein (ORP-150)' in human brain and its relationship with duration time until death. Leg Med(Tokyo) , 6:97-101. 2004
  6. Mori R, Kondo T, Nishie T, Ohshima T, Asano M. Impairment of skin wound healing in　　b-1,4-galactosyltransferase-deficient mice with reduced leukocyte recruitment. Am J Pathol, 164: 1303-1314. 2004
  7. Kishino M, Yukawa K, Hoshino K, Kimura A, Shirasawa N, Otani H, Tanaka T, Owada-Makabe K, Tsubota Y, Maeda M, Akira S and Mune M. Deletion of the Kinase Domain in Death-Associated Protein Kinase Attenuates Tubular Cell Apoptosis in Renal Ischemia-Reperfusion Injury. J Am Soc Nephrol, 15:1826-1834. 2004
  8. Amano H, Morimoto K, Senba M, Wang H, Ishida Y, Kumatori A, Yoshimine H, Oishi K, Mukaida N, Nagatake T. Essential Contribution of Monocyte Chemoattractant Protein-1/C-C Chemokine Ligand-2 to Resolution and Repair Processes in Acute Bacterial Pneumonia. J Immunol. 172:398-407. 2004
  9. Wada T, Furuichi K, Sakai N, Iwata Y, Kitagawa K, Ishida Y, Kondo T, Hashimoto H, Ishiwata Y, Mukaida N, Tomosugi N, Matsushima K, Egashira K, Yokoyama H. Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis. J Am Soc Nephrol, 15:940-948. 2004
  10. Nakamura M, Kyo S, Kanaya T, Yatabe N, Maida Y, Tanaka M, Ishida Y, Fujii C, Kondo T, Inoue M, Mukaida N. hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitizes cervical cancer cells to a low dose of cisplatin. Cancer Gene Ther, 11:1-7. 2004
  11. Tomita Y, Yang X, Ishida Y, Nemoto-Sasaki Y, Kondo T, Oda M, Watanabe G, Chaldakov GN, Fujii C, Mukaida N. Spontaneous regression of lung metastasis in the absence of tumor necrosis factor receptor p55. Int J Cancer, 112:927-933. 2004
  12. Minami Y, Uede K, Sagawa K, Kimura A, Tsuji T, Furukawa F. Immunohistochemical staining of cutaneous tumours with G-81, a monoclonal antibody to dermcidin. Br J Dermatol, 151:165-169. 2004
  13. Minami Y, Uede K, Furukawa F, Sagawa K, Kimura A, Tsuji T. Cutaneous mixed tumors: an immunohistochemical study using two antibodies, G-81 and C8/144B. J Dermatol Sci, 36:180-182. 2004
  14. Yukawa K, Shirasawa N, Ohshima A, Mune M, Kimura A, Tao Bai, Tsubota Y, Owada-Makabe K, Tanaka T, Kishino M, Tsuruo Y, Umesaki N, Maeda M. Death-associated protein Kinase localization to human renal tubule cells, and increased expression of chronic obstructive uropathy in rats. J Nephrol, 17:26-33. 2004
  15. Yukawa K, Hoshino K, Kishino M, Mune M, Shirasawa N, Kimura A, Tsubota Y, Owada-Makabe K, Tanaka T, Ichinose M, Maeda M, Takeda K, Akira S. Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy. Int J Mol Med 13:515-520. 2004
  16. 石田裕子，近藤稔和，向田直史．Clostridium difficile toxin A 誘発腸炎におけるIFN-gの役割．臨床免疫, 42:474-476. 2004
  17. 近藤稔和．皮膚創傷治癒－法医学から分子病理学．和歌山医学，55:2-6. 2004
  1. Tanaka J, Ishida Y, Ohshima T, Kondo T. The gene expression of cytokines and chemokines induced by tourniquet shock in mice. Leg Med, 5:146-155. 2003
  2. Wang H, Nemoto-Sasaki Y, Kondo T, Akiyama M, Mukaida N.Potential involvement of monocyte chemoattractant protein (MCP)-1/CCL2 in IL-4-mediated tumor immunity through inducing dendritic cell migration into the draining nodes. Int Immunopharmacol, 3:627-642. 2003
  3. Lin ZQ, Kondo T, Ishida Y, Takayasu T, Mukaida N. Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice. J Leukoc Biol, 73:713-721. 2003
  4. Popivanova BK1, Koike K, Tonchev AB, Ishida Y, Kondo T, Ogawa S, Mukaida N, Inoue M, Yamashima T. Accumulation of microglial cells expressing ELR motif-positive CXC chemokines and their receptor CXCR2 in monkey hippocampus after ischemia-reperfusion. Brain Res, 970:195-204. 2003

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